Pesquisa | BVS Violência e Saúde

1.

Embracing cancer complexity: Hallmarks of systemic disease.

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas.

Cell ; 187(7): 1589-1616, 2024 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-38552609

2.

Fibroblasts in cancer: Unity in heterogeneity.

Chhabra, Yash; Weeraratna, Ashani T.

Cell ; 186(8): 1580-1609, 2023 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-37059066

3.

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Walton, Zandra E; Patel, Chirag H; Brooks, Rebekah C; Yu, Yongjun; Ibrahim-Hashim, Arig; Riddle, Malini; Porcu, Alessandra; Jiang, Tianying; Ecker, Brett L; Tameire, Feven; Koumenis, Constantinos; Weeraratna, Ashani T; Welsh, David K; Gillies, Robert; Alwine, James C; Zhang, Lin; Powell, Jonathan D; Dang, Chi V.

Cell ; 174(1): 72-87.e32, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29861175

4.

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells.

Goyal, Yogesh; Busch, Gianna T; Pillai, Maalavika; Li, Jingxin; Boe, Ryan H; Grody, Emanuelle I; Chelvanambi, Manoj; Dardani, Ian P; Emert, Benjamin; Bodkin, Nicholas; Braun, Jonas; Fingerman, Dylan; Kaur, Amanpreet; Jain, Naveen; Ravindran, Pavithran T; Mellis, Ian A; Kiani, Karun; Alicea, Gretchen M; Fane, Mitchell E; Ahmed, Syeda Subia; Li, Haiyin; Chen, Yeqing; Chai, Cedric; Kaster, Jessica; Witt, Russell G; Lazcano, Rossana; Ingram, Davis R; Johnson, Sarah B; Wani, Khalida; Dunagin, Margaret C; Lazar, Alexander J; Weeraratna, Ashani T; Wargo, Jennifer A; Herlyn, Meenhard; Raj, Arjun.

Nature ; 620(7974): 651-659, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37468627

5.

Stromal changes in the aged lung induce an emergence from melanoma dormancy.

Fane, Mitchell E; Chhabra, Yash; Alicea, Gretchen M; Maranto, Devon A; Douglass, Stephen M; Webster, Marie R; Rebecca, Vito W; Marino, Gloria E; Almeida, Filipe; Ecker, Brett L; Zabransky, Daniel J; Hüser, Laura; Beer, Thomas; Tang, Hsin-Yao; Kossenkov, Andrew; Herlyn, Meenhard; Speicher, David W; Xu, Wei; Xu, Xiaowei; Jaffee, Elizabeth M; Aguirre-Ghiso, Julio A; Weeraratna, Ashani T.

Nature ; 606(7913): 396-405, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35650435

6.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Webster, Marie R; Fane, Mitchell E; Alicea, Gretchen M; Basu, Subhasree; Kossenkov, Andrew V; Marino, Gloria E; Douglass, Stephen M; Kaur, Amanpreet; Ecker, Brett L; Gnanapradeepan, Keerthana; Ndoye, Abibatou; Kugel, Curtis; Valiga, Alexander; Palmer, Jessica; Liu, Qin; Xu, Xiaowei; Morris, Jessicamarie; Yin, Xiangfan; Wu, Hong; Xu, Wei; Zheng, Cathy; Karakousis, Giorgos C; Amaravadi, Ravi K; Mitchell, Tara C; Almeida, Filipe V; Xiao, Min; Rebecca, Vito W; Wang, Ying-Jie; Schuchter, Lynn M; Herlyn, Meenhard; Murphy, Maureen E; Weeraratna, Ashani T.

Mol Cell ; 77(3): 633-644.e5, 2020 02 06.

Artigo em Inglês | MEDLINE | ID: mdl-31836388

7.

ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ.

Dardani, Ian; Emert, Benjamin L; Goyal, Yogesh; Jiang, Connie L; Kaur, Amanpreet; Lee, Jasmine; Rouhanifard, Sara H; Alicea, Gretchen M; Fane, Mitchell E; Xiao, Min; Herlyn, Meenhard; Weeraratna, Ashani T; Raj, Arjun.

Nat Methods ; 19(11): 1403-1410, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36280724

8.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

Webster, Marie R; Fane, Mitchell E; Alicea, Gretchen M; Basu, Subhasree; Kossenkov, Andrew V; Marino, Gloria E; Douglass, Stephen M; Kaur, Amanpreet; Ecker, Brett L; Gnanapradeepan, Keerthana; Ndoye, Abibatou; Kugel, Curtis; Valiga, Alexander; Palmer, Jessica; Liu, Qin; Xu, Xiaowei; Morris, Jessicamarie; Yin, Xiangfan; Wu, Hong; Xu, Wei; Zheng, Cathy; Karakousis, Giorgos C; Amaravadi, Ravi K; Mitchell, Tara C; Almeida, Filipe V; Xiao, Min; Rebecca, Vito W; Wang, Ying-Jie; Schuchter, Lynn M; Herlyn, Meenhard; Murphy, Maureen E; Weeraratna, Ashani T.

Mol Cell ; 77(3): 681, 2020 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-32032511

9.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur, Amanpreet; Webster, Marie R; Marchbank, Katie; Behera, Reeti; Ndoye, Abibatou; Kugel, Curtis H; Dang, Vanessa M; Appleton, Jessica; O'Connell, Michael P; Cheng, Phil; Valiga, Alexander A; Morissette, Rachel; McDonnell, Nazli B; Ferrucci, Luigi; Kossenkov, Andrew V; Meeth, Katrina; Tang, Hsin-Yao; Yin, Xiangfan; Wood, William H; Lehrmann, Elin; Becker, Kevin G; Flaherty, Keith T; Frederick, Dennie T; Wargo, Jennifer A; Cooper, Zachary A; Tetzlaff, Michael T; Hudgens, Courtney; Aird, Katherine M; Zhang, Rugang; Xu, Xiaowei; Liu, Qin; Bartlett, Edmund; Karakousis, Giorgos; Eroglu, Zeynep; Lo, Roger S; Chan, Matthew; Menzies, Alexander M; Long, Georgina V; Johnson, Douglas B; Sosman, Jeffrey; Schilling, Bastian; Schadendorf, Dirk; Speicher, David W; Bosenberg, Marcus; Ribas, Antoni; Weeraratna, Ashani T.

Nature ; 532(7598): 250-4, 2016 Apr 14.

Artigo em Inglês | MEDLINE | ID: mdl-27042933

10.

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.

Ahmadzadeh, Hossein; Webster, Marie R; Behera, Reeti; Jimenez Valencia, Angela M; Wirtz, Denis; Weeraratna, Ashani T; Shenoy, Vivek B.

Proc Natl Acad Sci U S A ; 114(9): E1617-E1626, 2017 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-28196892

11.

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC).

Alves-Fernandes, Débora Kristina; Oliveira, Érica Aparecida de; Faião-Flores, Fernanda; Alicea-Rebecca, Gretchen; Weeraratna, Ashani T; Smalley, Keiran S M; Barros, Silvia Berlanga de Moraes; Maria-Engler, Silvya Stuchi.

Pharmacol Res ; 141: 63-72, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30550954

12.

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Caino, M Cecilia; Ghosh, Jagadish C; Chae, Young Chan; Vaira, Valentina; Rivadeneira, Dayana B; Faversani, Alice; Rampini, Paolo; Kossenkov, Andrew V; Aird, Katherine M; Zhang, Rugang; Webster, Marie R; Weeraratna, Ashani T; Bosari, Silvano; Languino, Lucia R; Altieri, Dario C.

Proc Natl Acad Sci U S A ; 112(28): 8638-43, 2015 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-26124089

13.

Genetically-defined ovarian cancer mouse models.

Morin, Patrice J; Weeraratna, Ashani T.

J Pathol ; 238(2): 180-4, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26496815

14.

Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Kaur, Amanpreet; Webster, Marie R; Marchbank, Katie; Behera, Reeti; Ndoye, Abibatou; Kugel, Curtis H; Dang, Vanessa M; Appleton, Jessica; O'Connell, Michael P; Cheng, Phil; Valiga, Alexander A; Morissette, Rachel; McDonnell, Nazli B; Ferrucci, Luigi; Kossenkov, Andrew V; Meeth, Katrina; Tang, Hsin-Yao; Yin, Xiangfan; Wood, William H; Lehrmann, Elin; Becker, Kevin G; Flaherty, Keith T; Frederick, Dennie T; Wargo, Jennifer A; Cooper, Zachary A; Tetzlaff, Michael T; Hudgens, Courtney; Aird, Katherine M; Zhang, Rugang; Xu, Xiaowei; Liu, Qin; Bartlett, Edmund; Karakousis, Giorgos; Eroglu, Zeynep; Lo, Roger S; Chan, Matthew; Menzies, Alexander M; Long, Georgina V; Johnson, Douglas B; Sosman, Jeffrey; Schilling, Bastian; Schadendorf, Dirk; Speicher, David W; Bosenberg, Marcus; Ribas, Antoni; Weeraratna, Ashani T.

Nature ; 537(7619): 254, 2016 Sep 08.

Artigo em Inglês | MEDLINE | ID: mdl-27383789

15.

The Wnts of change: How Wnts regulate phenotype switching in melanoma.

Webster, Marie R; Kugel, Curtis H; Weeraratna, Ashani T.

Biochim Biophys Acta ; 1856(2): 244-51, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26546268

16.

In the Wnt-er of life: Wnt signalling in melanoma and ageing.

Kaur, Amanpreet; Webster, Marie R; Weeraratna, Ashani T.

Br J Cancer ; 115(11): 1273-1279, 2016 Nov 22.

Artigo em Inglês | MEDLINE | ID: mdl-27764844

17.

Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.

Tavecchio, Michele; Lisanti, Sofia; Lam, Aaron; Ghosh, Jagadish C; Martin, Nina M; O'Connell, Michael; Weeraratna, Ashani T; Kossenkov, Andrew V; Showe, Louise C; Altieri, Dario C.

J Biol Chem ; 288(8): 5553-61, 2013 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-23303179

18.

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.

Marino-Bravante, Gloria E; Carey, Alexis E; Hüser, Laura; Dixit, Agrani; Wang, Vania; Kaur, Amanpreet; Liu, Ying; Ding, Supeng; Schnellmann, Rahel; Gerecht, Sharon; Gu, Luo; Eisinger-Mathason, T S Karin; Chhabra, Yash; Weeraratna, Ashani T.

Nat Aging ; 4(3): 350-363, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38472454

19.

Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.

Zhang, Xue; Pant, Shishir M; Ritch, Cecily C; Tang, Hsin-Yao; Shao, Hongguang; Dweep, Harsh; Gong, Yao-Yu; Brooks, Rebekah; Brafford, Patricia; Wolpaw, Adam J; Lee, Yool; Weeraratna, Ashani; Sehgal, Amita; Herlyn, Meenhard; Kossenkov, Andrew; Speicher, David; Sorger, Peter K; Santagata, Sandro; Dang, Chi V.

Nat Commun ; 15(1): 633, 2024 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-38245503

20.

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.

Zabransky, Daniel J; Chhabra, Yash; Fane, Mitchell E; Kartalia, Emma; Leatherman, James M; Hüser, Laura; Zimmerman, Jacquelyn W; Delitto, Daniel; Han, Song; Armstrong, Todd D; Charmsaz, Soren; Guinn, Samantha; Pramod, Sneha; Thompson, Elizabeth D; Hughes, Steven J; O'Connell, Jennifer; Egan, Josephine M; Jaffee, Elizabeth M; Weeraratna, Ashani T.

Cancer Res ; 84(8): 1221-1236, 2024 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-38330147

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Embracing cancer complexity: Hallmarks of systemic disease.

Fibroblasts in cancer: Unity in heterogeneity.

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells.

Stromal changes in the aged lung induce an emergence from melanoma dormancy.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ.

Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC).

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Genetically-defined ovarian cancer mouse models.

Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.

The Wnts of change: How Wnts regulate phenotype switching in melanoma.

In the Wnt-er of life: Wnt signalling in melanoma and ageing.

Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.

Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.

Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.